Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

Nature Reviews Cancer 7, 684-700 (September 2007) | doi:10.1038/nrc2196

by

Kristin K. Deeb, Donald L. Trump & Candace S. Johnson

 

Abstract

Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1α,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1α,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1α,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.

http://www.nature.com/nrc/journal/v7/n9/full/nrc2196.html

 

FIGURE 1 | Vitamin D metabolism.

From the following article:

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

Kristin K. Deeb, Donald L. Trump & Candace S. Johnson

Nature Reviews Cancer 7, 684-700 (September 2007)

doi:10.1038/nrc2196

FIGURE 1 | Vitamin D metabolism.

From the following article:

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

Kristin K. Deeb, Donald L. Trump & Candace S. Johnson

Nature Reviews Cancer 7, 684-700 (September 2007)

doi:10.1038/nrc2196

http://www.nature.com/nrc/journal/v7/n9/fig_tab/nrc2196_F1.html

 

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