O papel da vitamina D na Esclerose Múltipla – Brown 40 (6): 1158…

O papel da vitamina D na Esclerose Múltipla – Brown 40 (6): 1158…

Published Online, 9 May 2006, http://www.theannals.com, DOI 10.1345/aph.1G513.
The Annals of Pharmacotherapy: Vol. 40, No. 6, pp. 1158-1161. DOI 10.1345/aph.1G513
© 2006 Harvey Whitney Books Company.
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Articles by Brown, S. J
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Articles by Brown, S. J

DRUG INFORMATION ROUNDS
The Role of Vitamin D in Multiple Sclerosis
Sherrill J Brown, DVM PharmD1
1 Director, Drug Information Service, Skaggs School of Pharmacy, College of Health Professions and Biomedical Sciences, The University of Montana, 32 Campus Dr. Skaggs, Bldg 217, Missoula, MT 59812-1522, fax 406/243-4353, sherrill.brown@umontana.edux

Reprints: Dr. Brown

OBJECTIVE: To evaluate the literature about the role of vitamin D in the prevention and treatment of multiple sclerosis (MS).

DATA SOURCES: MEDLINE (1966-April 2006) and International Pharmaceutical Abstracts (1970-April 2006) searches were performed. In addition, pertinent references from identified articles were obtained. Key search terms included vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, and multiple sclerosis.

DATA SYNTHESIS: Vitamin D supplementation prevented the development and progression of experimental autoimmune encephalitis, an animal model of MS, in mice. A large, prospective, cohort study found that vitamin D supplementation was associated with a 40% reduction in the risk of developing MS. Four small, noncontrolled studies suggested that vitamin D supplementation may decrease exacerbation of MS symptoms.

CONCLUSIONS: Vitamin D supplementation may help prevent the development of MS and may be a useful addition to therapy. However, current studies are in small populations and are confounded by other variables, such as additional vitamin and mineral supplementation.

Key Words: multiple sclerosis, vitamin D

Published Online, May 9, 2006. http://www.theannals.com, DOI 10.1345/aph.1G513

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http://www.theannals.com/cgi/content/abstract/40/6/1158

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Article: DRUG INFORMATION ROUNDS: The Role of Vitamin D in Multiple Sclerosis
  • Sherrill J Brown
Ann Pharmacother June 2006 40:1158-1161; published ahead of print May 9, 2006,
 
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ARTICLE

The Role of Vitamin D in Multiple Sclerosis

  1. Sherrill J Brown, DVM PharmD1

+ Author Affiliations


  1. 1Director, Drug Information Service, Skaggs School of Pharmacy, College of Health Professions and Biomedical Sciences, The University of Montana, 32 Campus Dr. Skaggs, Bldg 217, Missoula, MT 59812-1522, fax 406/243-4353, sherrill.brown@umontana.edux
  1. Reprints: Dr. Brown

Abstract

OBJECTIVE: To evaluate the literature about the role of vitamin D in the prevention and treatment of multiple sclerosis (MS).

DATA SOURCES: MEDLINE (1966-April 2006) and International Pharmaceutical Abstracts (1970-April 2006) searches were performed. In addition, pertinent references from identified articles were obtained. Key search terms included vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, and multiple sclerosis.

DATA SYNTHESIS: Vitamin D supplementation prevented the development and progression of experimental autoimmune encephalitis, an animal model of MS, in mice. A large, prospective, cohort study found that vitamin D supplementation was associated with a 40% reduction in the risk of developing MS. Four small, noncontrolled studies suggested that vitamin D supplementation may decrease exacerbation of MS symptoms.

CONCLUSIONS: Vitamin D supplementation may help prevent the development of MS and may be a useful addition to therapy. However, current studies are in small populations and are confounded by other variables, such as additional vitamin and mineral supplementation

disponivel em

http://www.theannals.com/content/40/6/1158.abstract

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